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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation

Every additional millilitre of bacteriostatic water dilutes the solution further and increases the volume required to achieve the same dose

Diamanti-Kandarakis E, Piperi C, Kalofoutis A, Creatsas G

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